"An investment in knowledge pays the best interest."



Drug Manufacture

Promis Neurosciences Inc. (PMN.T)  has initiated producer cell line development for PMN310, its lead therapeutic antibody candidate for treatment of Alzheimer's disease (AD). Selexis SA will carry out this critical first step in the manufacturing of antibody therapeutics using the proprietary Selexis SUREtechnology platform.

ProMIS' lead antibody product candidate, PMN310, is a humanized antibody that binds with high affinity and selectivity for the toxic oligomers of amyloid beta (As), a recognized root cause of AD. PMN310 is anticipated to enter phase I clinical trials in the second half of 2019.

"We recently completed successful affinity maturation of PMN310, which in addition to its unique and highly selective binding profile offers increased opportunity for best in class therapy for Alzheimer's disease," said Dr. Elliot Goldstein, ProMIS President and CEO. "We are now initiating the manufacturing process with Selexis' proprietary, high-performance technology platform for cell line development based on its proven track record for rapid and stable production of antibody therapeutics such as PMN310."

Selexis' proprietary and high performance SUREtechnology Platform facilitates the rapid, stable and cost-effective production of virtually any recombinant protein including those that are difficult to express in other systems.

"It is rewarding for us to leverage the fast speed/timelines and superior performance of the Selexis platform to rapidly and predictably advance PMN310 into the clinic with the goal of supporting ProMIS Neurosciences as they seek to bring a much needed treatment option to patients with Alzheimer's disease," said Yemi Onakunle, PhD, Selexis vice president, business development and licensing. "We believe our best-in-class technology can help propel forward this best-in-class therapeutic candidate."

About ProMIS Neurosciences, Inc.

ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing precision medicine therapeutics to treat neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform-ProMIS(TM) and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.